Trifluoroethanol as a metal-free, homogeneous and recyclable medium for the efficient one-pot synthesis of α-amino nitriles and α-amino phosphonates

被引：69

作者：

Heydari, Akbar ^{[1
]}

Khaksar, Samad ^{[1
]}

Tajbakhsh, Mahmood ^{[2
]}

机构：

[1] Tarbiat Modares Univ, Dept Chem, Tehran, Iran

[2] Mazandaran Univ, Dept Chem, Babol Sar 47415, Iran

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 01期

关键词：

Fluorous solvents; Trimethylsilyl cyanide; Trifluoroethanol; alpha-Amino phosphonates; alpha-Amino nitriles; Hydrogen bonding; ORGANIC PHOSPHORUS-COMPOUNDS; FACILE SYNTHESIS; ENANTIOSELECTIVE ADDITION; 3-COMPONENT CONDENSATION; LANTHANIDE TRIFLATE; SOLVENT-FREE; ACID; ALDEHYDES; CATALYST; AMINOPHOSPHONATES;

D O I：

10.1016/j.tetlet.2008.10.106

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Trifluoroethanol is found to be an efficient and recyclable medium in promoting one-pot, three-component coupling reactions of aldehydes or ketones, amines and trimethylsilyl cyanide or trimethyl phosphite to afford the corresponding (alpha-amino nitriles or alpha-amino phosphonates in high yields. This protocol does not require the use of an acid or base catalyst. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：77 / 80

页数：4

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