Glycopeptides as versatile tools for glycobiology

被引:141
作者
Buskas, Therese [1 ]
Ingale, Sampat [1 ]
Boons, Geert-Jan [1 ]
机构
[1] Univ Georgia, Complex Carbohydrate Res Ctr, Athens, GA 30602 USA
关键词
glycobiology; glycopeptides; glycoproteins; oligosaccharide; synthesis;
D O I
10.1093/glycob/cwj125
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This review describes the recent advances in the field of glycopeptide and small glycoprotein synthesis. The strategies covered include chemical and chemoenzymatic synthesis, native chemical ligation (NCL), and expressed chemical ligation. The importance of glycopeptide synthesis is exemplified by giving the reader an overview of how versatile and important these well-defined glycopeptides are as tools in glycobiology.
引用
收藏
页码:113R / 136R
页数:24
相关论文
共 196 条
[51]   Genetic optimization of recombinant glycoprotein production by mammalian cells [J].
Fussenegger, M ;
Bailey, JE ;
Hauser, H ;
Mueller, PP .
TRENDS IN BIOTECHNOLOGY, 1999, 17 (01) :35-42
[52]   Advances in the production of human therapeutic proteins in yeasts and filamentous fungi [J].
Gerngross, TU .
NATURE BIOTECHNOLOGY, 2004, 22 (11) :1409-1414
[53]   Biopharmaceutical production in plants: problems, solutions and opportunities [J].
Gomord, W ;
Chamberlain, P ;
Jefferis, R ;
Faye, L .
TRENDS IN BIOTECHNOLOGY, 2005, 23 (11) :559-565
[54]   Heparan sulfate and development:: differential roles of the N-acetylglucosamine N-deacetylase/N-sulfotransferase isozymes [J].
Grobe, K ;
Ledin, J ;
Ringvall, M ;
Holmborn, K ;
Forsberg, E ;
Esko, JD ;
Kjellén, L .
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2002, 1573 (03) :209-215
[55]   Homogeneous glycopeptides and glycoproteins for biological investigation [J].
Grogan, MJ ;
Pratt, MR ;
Marcaurelle, LA ;
Bertozzi, CR .
ANNUAL REVIEW OF BIOCHEMISTRY, 2002, 71 :593-634
[56]   Glycopeptide and glycoprotein synthesis involving unprotected carbohydrate building blocks [J].
Guo, ZW ;
Shao, N .
MEDICINAL RESEARCH REVIEWS, 2005, 25 (06) :655-678
[57]   Total chemical synthesis of enzymatically active human type II secretory phospholipase A(2) [J].
Hackeng, TM ;
Mounier, CM ;
Bon, C ;
Dawson, PE ;
Griffin, JH ;
Kent, SBH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (15) :7845-7850
[58]  
Hakamori S, 1998, ACTA ANAT, V161, P79
[59]   Modulation of receptor signaling by glycosylation:: fringe is an O-fucose-β1,3-N-acetylglucosaminyltransferase [J].
Haltiwanger, RS ;
Stanley, P .
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2002, 1573 (03) :328-335
[60]   Regulation of signal transduction pathways in development by glycosylation [J].
Haltiwanger, RS .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 2002, 12 (05) :593-598