Synthesis of immunoreagents for measurement of galactosylhydroxylysine

被引：5

作者：

Adamczyk, M ^{[1
]}

Reddy, RE ^{[1
]}

机构：

[1] Abbott Labs, Div Diagnost, Div Organ Chem Res, Abbott Pk, IL 60064 USA

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 16期

关键词：

D O I：

10.1016/S0957-4166(99)00331-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 [无机化学]; 081704 [应用化学];

摘要：

(2S,5R)-(+)-Hydroxylysine (6) was transformed into (-)-succinimidyl ester (13) and conjugated to BSA or KLH to form immunogens (2 and 3) for generation of anti-galactosylhydroxylysine antibodies. Additionally, treatment of (-)-13 with 6-Fln-CH2NH2 (16) or acridinium derivative (17) and subsequent hydrolysis gave the fluorescent (4) and chemiluminescent (5) tracers, respectively. These immunoreagents (3,4 and 5,6) are essential for development of assays for diagnosis of osteoporosis. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：3157 / 3165

页数：9

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