The SWI/SNF complex and cancer

被引：470

作者：

Reisman, D. ^{[1
]}

Glaros, S.

Thompson, E. A. ^{[2
]}

机构：

[1] Univ Michigan, Dept Internal Med, Coll Med, Div Hematol Oncol, Ann Arbor, MI 48109 USA

[2] Mayo Clin, Ctr Comprehens Canc, Dept Canc Biol, Jacksonville, FL 32224 USA

来源：

ONCOGENE | 2009年 / 28卷 / 14期

关键词：

BRG1; BRM; BAF47; tumor suppressor; chromatin remodeling; CHROMATIN-REMODELING COMPLEX; SWI-SNF COMPLEX; TUMOR-SUPPRESSOR GENE; GLUCOCORTICOID-INDUCED APOPTOSIS; CELL-CYCLE ARREST; LUNG-CANCER; ESTROGEN-RECEPTOR; NUCLEAR RECEPTOR; ATPASE SUBUNIT; TRANSCRIPTIONAL ACTIVATION;

D O I：

10.1038/onc.2009.4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mammalian SWI/SNF complexes mediate ATP-dependent chromatin remodeling processes that are critical for differentiation and proliferation. Not surprisingly, loss of SWI/SNF function has been associated with malignant transformation, and a substantial body of evidence indicates that several components of the SWI/SNF complexes function as tumor suppressors. This review summarizes the evidence that underlies this conclusion, with particular emphasis upon the two catalytic subunits of the SWI/SNF complexes, BRM, the mammalian ortholog of SWI2/SNF2 in yeast and brahma in Drosophila, and Brahma-related gene-1 (BRG1).

引用

页码：1653 / 1668

页数：16

共 216 条

[1] MOLECULAR ANALYSIS OF SNF2 AND SNF5, GENES REQUIRED FOR EXPRESSION OF GLUCOSE-REPRESSIBLE GENES IN SACCHAROMYCES-CEREVISIAE [J].

ABRAMS, E ;

NEIGEBORN, L ;

CARLSON, M .

MOLECULAR AND CELLULAR BIOLOGY, 1986, 6 (11) :3643-3651

[2] Ordered recruitment of chromatin modifying and general transcription factors to the IFN-β promoter [J].

Agalioti, T ;

Lomvardas, S ;

Parekh, B ;

Yie, JM ;

Maniatis, T ;

Thanos, D .

CELL, 2000, 103 (04) :667-678

[3]

An HX, 1999, CANCER RES, V59, P3941

[4] ATP-dependent chromatin remodeling complexes and their role in nuclear receptor-dependent transcription in vivo [J].

Aoyagi, S ;

Trotter, KW ;

Archer, TK .

VITAMINS AND HORMONES, 2005, 70 :281-307

[5] The Drosophila BRM complex facilitates global transcription by RNA polymerase II [J].

Armstrong, JA ;

Papoulas, O ;

Daubresse, G ;

Sperling, AS ;

Lis, JT ;

Scott, MP ;

Tamkun, JW .

EMBO JOURNAL, 2002, 21 (19) :5245-5254

[6] A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro [J].

Armstrong, JA ;

Bieker, JJ ;

Emerson, BM .

CELL, 1998, 95 (01) :93-104

[7] SWI/SNF chromatin-remodeling factors induce changes in DNA methylation to promote transcriptional activation [J].

Banine, F ;

Bartlett, C ;

Gunawardena, R ;

Muchardt, C ;

Yaniv, M ;

Knudsen, ES ;

Weissman, BE ;

Sherman, LS .

CANCER RESEARCH, 2005, 65 (09) :3542-3547

[8] The human SWI/SNF subunit Brm is a regulator of alternative splicing [J].

Batsché, E ;

Yaniv, M ;

Muchardt, C .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2006, 13 (01) :22-29

[9] Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes [J].

Belandia, B ;

Orford, RL ;

Hurst, HC ;

Parker, MG .

EMBO JOURNAL, 2002, 21 (15) :4094-4103

[10]

Biegel JA, 2000, CLIN CANCER RES, V6, P2759

← 1 2 3 4 5 6 7 8 9 10 →