The SWI/SNF complex and cancer

被引：470

作者：

Reisman, D. ^{[1
]}

Glaros, S.

Thompson, E. A. ^{[2
]}

机构：

[1] Univ Michigan, Dept Internal Med, Coll Med, Div Hematol Oncol, Ann Arbor, MI 48109 USA

[2] Mayo Clin, Ctr Comprehens Canc, Dept Canc Biol, Jacksonville, FL 32224 USA

来源：

ONCOGENE | 2009年 / 28卷 / 14期

关键词：

BRG1; BRM; BAF47; tumor suppressor; chromatin remodeling; CHROMATIN-REMODELING COMPLEX; SWI-SNF COMPLEX; TUMOR-SUPPRESSOR GENE; GLUCOCORTICOID-INDUCED APOPTOSIS; CELL-CYCLE ARREST; LUNG-CANCER; ESTROGEN-RECEPTOR; NUCLEAR RECEPTOR; ATPASE SUBUNIT; TRANSCRIPTIONAL ACTIVATION;

D O I：

10.1038/onc.2009.4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mammalian SWI/SNF complexes mediate ATP-dependent chromatin remodeling processes that are critical for differentiation and proliferation. Not surprisingly, loss of SWI/SNF function has been associated with malignant transformation, and a substantial body of evidence indicates that several components of the SWI/SNF complexes function as tumor suppressors. This review summarizes the evidence that underlies this conclusion, with particular emphasis upon the two catalytic subunits of the SWI/SNF complexes, BRM, the mammalian ortholog of SWI2/SNF2 in yeast and brahma in Drosophila, and Brahma-related gene-1 (BRG1).

引用

页码：1653 / 1668

页数：16

共 216 条

[71] EVIDENCE THAT SNF2/SWI2 AND SNF5 ACTIVATE TRANSCRIPTION IN YEAST BY ALTERING CHROMATIN STRUCTURE [J].

HIRSCHHORN, JN ;

BROWN, SA ;

CLARK, CD ;

WINSTON, F .

GENES & DEVELOPMENT, 1992, 6 (12A) :2288-2298

[72] Modulation of androgen receptor transactivation by the SW13-related gene product (SRG3) in multiple ways [J].

Hong, CY ;

Suh, JH ;

Kim, K ;

Gong, EY ;

Jeon, SH ;

Ko, M ;

Seong, RH ;

Kwon, HB ;

Lee, K .

MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (12) :4841-4852

[73] BAF60a mediates critical interactions between nuclear receptors and the BRG1 chromatin-remodeling complex for transactivation [J].

Hsiao, PW ;

Fryer, CJ ;

Trotter, KW ;

Wang, WD ;

Archer, TK .

MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (17) :6210-6220

[74] Genomic and functional evidence for an ARID 1A tumor suppressor role [J].

Huang, Jianmin ;

Zhao, Yan-Ling ;

Li, Yu ;

Fletcher, Jonathan A. ;

Xiao, Sheng .

GENES CHROMOSOMES & CANCER, 2007, 46 (08) :745-750

[75] Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-α-inducible genes [J].

Huang, M ;

Qian, F ;

Hu, YY ;

Ang, CG ;

Li, Z ;

Wen, ZL .

NATURE CELL BIOLOGY, 2002, 4 (10) :774-781

[76] Cloning and characterization of hELD/OSA1, a novel BRG1 interacting protein [J].

Hurlstone, AFL ;

Olave, IA ;

Barker, N ;

van Noort, M ;

Clevers, H .

BIOCHEMICAL JOURNAL, 2002, 364 (01) :255-264

[77] Ligand-dependent interaction between the estrogen receptor and the human homologues of SWI2/SNF2 [J].

Ichinose, H ;

Garnier, JM ;

Chambon, P ;

Losson, R .

GENE, 1997, 188 (01) :95-100

[78] FACILITATED BINDING OF TATA-BINDING PROTEIN TO NUCLEOSOMAL DNA [J].

IMBALZANO, AN ;

KWON, H ;

GREEN, MR ;

KINGSTON, RE .

NATURE, 1994, 370 (6489) :481-485

[79] Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation [J].

Indra, AK ;

Dupé, V ;

Bornert, JM ;

Messaddeq, N ;

Yaniv, M ;

Mark, M ;

Chambon, P ;

Metzger, D .

DEVELOPMENT, 2005, 132 (20) :4533-4544

[80]

INOUE H, 2002, J BIOL CHEM, V27, P27

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