The SWI/SNF complex and cancer

被引：470

作者：

Reisman, D. ^{[1
]}

Glaros, S.

Thompson, E. A. ^{[2
]}

机构：

[1] Univ Michigan, Dept Internal Med, Coll Med, Div Hematol Oncol, Ann Arbor, MI 48109 USA

[2] Mayo Clin, Ctr Comprehens Canc, Dept Canc Biol, Jacksonville, FL 32224 USA

来源：

ONCOGENE | 2009年 / 28卷 / 14期

关键词：

BRG1; BRM; BAF47; tumor suppressor; chromatin remodeling; CHROMATIN-REMODELING COMPLEX; SWI-SNF COMPLEX; TUMOR-SUPPRESSOR GENE; GLUCOCORTICOID-INDUCED APOPTOSIS; CELL-CYCLE ARREST; LUNG-CANCER; ESTROGEN-RECEPTOR; NUCLEAR RECEPTOR; ATPASE SUBUNIT; TRANSCRIPTIONAL ACTIVATION;

D O I：

10.1038/onc.2009.4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mammalian SWI/SNF complexes mediate ATP-dependent chromatin remodeling processes that are critical for differentiation and proliferation. Not surprisingly, loss of SWI/SNF function has been associated with malignant transformation, and a substantial body of evidence indicates that several components of the SWI/SNF complexes function as tumor suppressors. This review summarizes the evidence that underlies this conclusion, with particular emphasis upon the two catalytic subunits of the SWI/SNF complexes, BRM, the mammalian ortholog of SWI2/SNF2 in yeast and brahma in Drosophila, and Brahma-related gene-1 (BRG1).

引用

页码：1653 / 1668

页数：16

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