Synthesis of trisubstituted indoles on the solid phase via palladium-mediated heteroannulation of internal alkynes

被引：96

作者：

Zhang, HC

Brumfield, KK

Maryanoff, BE

机构：

[1] Drug Discovery, R.W. Johnson Pharmaceutical Res. I., Spring House

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 14期

关键词：

D O I：

10.1016/S0040-4039(97)00417-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Palladium-mediated heteroannulation of internal alkynes with resin-bound o-iodoaniline derivatives 4 or Sa provided diverse trisubstituted indoles 6 in good yields. The facile reaction of trimethylsilylalkynes afforded resin-bound precursors useful for obtaining other 2-substituted indole derivatives, such as 12. (C) 1997 Elsevier Science Ltd.

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页码：2439 / 2442

页数：4

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