Bacterial heme sources: the role of heme, hemoprotein receptors and hemophores

被引:249
作者
Wandersman, C
Stojiljkovic, I
机构
[1] Inst Pasteur, CNRS, URA 1300, Unite Membranes Bacteriennes, F-75724 Paris 15, France
[2] Emory Univ, Dept Microbiol & Immunol, Atlanta, GA 30322 USA
关键词
D O I
10.1016/S1369-5274(00)00078-3
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The major mechanisms by which Gram-negative bacteria acquire heme from host heme-carrier proteins involve either direct binding to specific outer membrane receptors or release of bacterial hemophores that take up heme from host heme carriers and shuttle it back to specific receptors. The ability to interact with and remove heme from carrier proteins distinguishes heme from conceptually similar siderophore and vitamin B12 receptors. Recent genetic, biochemical and crystallization studies have started to unravel the mechanism and molecular interactions between heme-carrier proteins and components of bacterial heme assimilation systems.
引用
收藏
页码:215 / 220
页数:6
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