Chemodosimeter for CuII detection based on cyclic peptide nucleic acids

被引：55

作者：

Kovacs, Janos ^{[1
]}

Roedler, Thomas ^{[1
]}

Mokhir, Andriy ^{[1
]}

机构：

[1] Heidelberg Univ, Inst Anorgan Chem, D-69120 Heidelberg, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 46期

关键词：

analytical methods; copper; fluorescence; nucleic acids; peptide nucleic acids;

D O I：

10.1002/anie.200603391

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Copper-sensitive cycle: A cyclic peptide nucleic acid (PNA) that does not bind DNA and RNA can be prepared by placing an optimized linker between the termini. CuII ions, but not other tested metal ions, catalyze the transformation of the cyclic PNA into the linear PNA, which is a strong binder of nucleic acids (see picture). This effect is used for the fluorimetric detection of CuII. ssDNA = single-stranded DNA. (Chemical Equation Presented). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7815 / 7817

页数：3

共 40 条

[1] Photo-mediated gene activation using caged RNA/DNA in zebrafish embryos [J].

Ando, H ;

Furuta, T ;

Tsien, RY ;

Okamoto, H .

NATURE GENETICS, 2001, 28 (04) :317-325

[2]

BLOOMFIELD VA, 1999, NUCL ACIDS STRUCTURE, P794

[3] Zn2+ dependent DNA binders based on terminally modified peptide nucleic acids [J].

Boll, I ;

Kovbasyuk, L ;

Krämer, R ;

Oeser, T ;

Mokhir, A .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (10) :2781-2785

[4] Templated metal catalysis for single nucleotide specific DNA sequence detection [J].

Boll, I ;

Krämer, R ;

Brunner, J ;

Mokhir, A .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (21) :7849-7856

[5] Hybridization dependent cleavage of internally modified disulfide-peptide nucleic acids [J].

Boll, I ;

Krämer, R ;

Mokhir, A .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (03) :505-509

[6] Metal complex catalysis on a double stranded DNA template [J].

Boll, Iris ;

Jentzsch, Elmar ;

Kraemer, Roland ;

Mokhir, Andriy .

CHEMICAL COMMUNICATIONS, 2006, (32) :3447-3449

[7] Caged RNA: photo-control of a ribozyme reaction [J].

Chaulk, SG ;

MacMillan, AM .

NUCLEIC ACIDS RESEARCH, 1998, 26 (13) :3173-3178

[8] Signaling recognition events with fluorescent sensors and switches [J].

de Silva, AP ;

Gunaratne, HQN ;

Gunnlaugsson, T ;

Huxley, AJM ;

McCoy, CP ;

Rademacher, JT ;

Rice, TE .

CHEMICAL REVIEWS, 1997, 97 (05) :1515-1566

[9] Cyclic PNA-based compound directed against HIV-1 TAR RNA: modelling, liquid-phase synthesis and TAR binding [J].

Depecker, G ;

Patino, N ;

Di Giorgio, C ;

Terreux, R ;

Cabrol-Bass, D ;

Bailly, C ;

Aubertin, AM ;

Condom, R .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2004, 2 (01) :74-79

[10] A long-wavelength fluorescent chemodosimeter selective for Cu(II) ion in water [J].

Dujols, V ;

Ford, F ;

Czarnik, AW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (31) :7386-7387

← 1 2 3 4 →