Synthesis of ODNs containing 4-methylamino-1,8-naphthalimide as a fluorescence probe in DNA

被引：34

作者：

Kawai, K ^{[1
]}

Kawabata, K ^{[1
]}

Tojo, S ^{[1
]}

Majima, T ^{[1
]}

机构：

[1] Osaka Univ, Inst Sci & Ind Res, SANKEN, Ibaraki, Osaka 5670047, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(02)00404-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthesis and fluorescence properties of oligodeoxynucleotides containing 4-methylamino-1,8-naphthalimide (NI) have been described. NI was successfully incorporated into DNA without significant destabilization of DNA whilst retaining its high fluorescence quantum yield. The attachment site of the NI greatly affected its property as an energy acceptor in FRET analysis. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2363 / 2366

页数：4

共 27 条

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