High-throughput cell analysis using multiplexed array technologies

被引:42
作者
Beske, OE [1 ]
Goldbard, S [1 ]
机构
[1] Virtual Arrays, Sunnyvale, CA 94089 USA
关键词
D O I
10.1016/S1359-6446(02)02388-7
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The desire for more biologically relevant data from primary screening has resulted in a dramatic increase of cell-based assays in HTS labs. Consequently, new cell-array technologies are being developed to increase the quality and quantity of data emerging from such screens. These technologies take the form of both positional and non-positional formats, each with their own advantages. Notably, screens using these technologies generate databases of high-quality data that can be analyzed in ways currently not possible. The power of cell-based assays combined with new array and analytical technologies will enable the condensation of serial drug discovery processes, thereby decreasing the time and cost of taking a hit compound into clinical trials. Here, we compare array strategies being developed towards the goal of integrating multiplexed cell-based assays into HTS.
引用
收藏
页码:S131 / S135
页数:5
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