ATG Systems from the Protein Structural Point of View

被引：62

作者：

Noda, Nobuo N. ^{[2
]}

Ohsumi, Yoshinori ^{[1
]}

Inagaki, Fuyuhiko ^{[2
]}

机构：

[1] Natl Inst Basic Biol, Mol Cell Biol Div, Okazaki, Aichi 4448585, Japan

[2] Hokkaido Univ, Grad Sch Pharmaceut Sci, Dept Biol Struct, Sapporo, Hokkaido 0010021, Japan

来源：

CHEMICAL REVIEWS | 2009年 / 109卷 / 04期

关键词：

PRE-AUTOPHAGOSOMAL STRUCTURE; VACUOLE TARGETING PATHWAY; MEMBRANE-TRANSPORT MODULATOR; RECEPTOR-ASSOCIATED PROTEIN; IN-VITRO RECONSTITUTION; E3 LIGASE ACTIVITY; SACCHAROMYCES-CEREVISIAE; CRYSTAL-STRUCTURE; CONJUGATING ENZYME; MAMMALIAN AUTOPHAGY;

D O I：

10.1021/cr800459r

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A study revealed that Atg proteins were responsible for autophagosome formations and showed the structures of Atg8 homologues and enzymes modifying Atg8. The autophagy-specific phosphatidylinositol 3-kinase complex produced phosphatidylinositol 3-phosphase and the localization of this complex were determined by Atg14. The crystal structure of S. cerevisiae Atg8 was determined as a complex with a peptide derived from Atg19, which was similar to mammalian homologues comprising the N-terminal helical domain and the C-terminal ubiquitin-like domain. It was observed that the Atg protein was made of various functional group like Atg1 kinase and its regulators, an autophagy-specific phosphatidylinositol 3-kinase complex, the integral membrane protein Atg9, and the Atg2-Atg18 complex. The structural study of Atg proteins provided an insight of mechanism of autophagasome formation.

引用

页码：1587 / 1598

页数：12

共 132 条

[81] Transport of phosphatidylinositol 3-phosphate into the vacuole via autophagic membranes in Saccharomyces cerevisiae [J].

Obara, Keisuke ;

Noda, Takeshi ;

Niimi, Kaori ;

Ohsumi, Yoshinori .

GENES TO CELLS, 2008, 13 (06) :537-547

[82] Physiological pH and acidic phospholipids contribute to substrate specificity in lipidation of Atg8 [J].

Oh-oka, Kyoko ;

Nakatogawa, Hitoshi ;

Ohsumi, Yoshinori .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (32) :21847-21852

[83] Molecular dissection of autophagy: Two ubiquitin-like systems [J].

Ohsumi, Y .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2001, 2 (03) :211-216

[84] p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy [J].

Pankiv, Serhiy ;

Clausen, Terje Hoyvarde ;

Lamark, Trond ;

Brech, Andreas ;

Bruun, Jack-Ansgar ;

Outzen, Heidi ;

Overvatn, Aud ;

Bjorkoy, Geir ;

Johansen, Terje .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (33) :24131-24145

[85] Structure of GATE-16, membrane transport modulator and mammalian ortholog of autophagocytosis factor Aut7p [J].

Paz, Y ;

Elazar, Z ;

Fass, D .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (33) :25445-25450

[86] Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin [J].

Penengo, L ;

Mapelli, M ;

Murachelli, AG ;

Confalonieri, S ;

Magri, L ;

Musacchio, A ;

Di Fiore, PP ;

Polo, S ;

Schneider, TR .

CELL, 2006, 124 (06) :1183-1195

[87] Ubiquitin: structures, functions, mechanisms [J].

Pickart, CM ;

Eddins, MJ .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2004, 1695 (1-3) :55-72

[88] Structure and functional interactions of the Tsg101 UEV domain [J].

Pornillos, O ;

Alam, SL ;

Rich, RL ;

Myszka, DG ;

Davis, DR ;

Sundquist, WI .

EMBO JOURNAL, 2002, 21 (10) :2397-2406

[89] Autophagosomes: biogenesis from scratch? [J].

Reggiori, F ;

Klionsky, DJ .

CURRENT OPINION IN CELL BIOLOGY, 2005, 17 (04) :415-422

[90] The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure [J].

Reggiori, F ;

Tucker, KA ;

Stromhaug, PE ;

Klionsky, DJ .

DEVELOPMENTAL CELL, 2004, 6 (01) :79-90

← 4 5 6 7 8 9 10 11 12 13 →