Addressing the problems with life-science databases for traditional uses and systems biology

被引：55

作者：

Philippi, Stephan

Koehler, Jacob

机构：

[1] Univ Koblenz, Dept Comp Sci, D-56016 Koblenz, Germany

[2] Rothamsted Res Harpenden, Biomath & Bioinformat Div, Harpenden AL5 2JQ, Herts, England

来源：

NATURE REVIEWS GENETICS | 2006年 / 7卷 / 06期

基金：

奥地利科学基金会;

关键词：

D O I：

10.1038/nrg1872

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A prerequisite to systems biology is the integration of heterogeneous experimental data, which are stored in numerous life-science databases. However, a wide range of obstacles that relate to access, handling and integration impede the efficient use of the contents of these databases. Addressing these issues will not only be essential for progress in systems biology, it will also be crucial for sustaining the more traditional uses of life-science databases.

引用

页码：482 / 488

页数：8

共 64 条

[1]

[Anonymous], SILICO BIOL

[2] Gene Ontology: tool for the unification of biology [J].

Ashburner, M ;

Ball, CA ;

Blake, JA ;

Botstein, D ;

Butler, H ;

Cherry, JM ;

Davis, AP ;

Dolinski, K ;

Dwight, SS ;

Eppig, JT ;

Harris, MA ;

Hill, DP ;

Issel-Tarver, L ;

Kasarskis, A ;

Lewis, S ;

Matese, JC ;

Richardson, JE ;

Ringwald, M ;

Rubin, GM ;

Sherlock, G .

NATURE GENETICS, 2000, 25 (01) :25-29

[3] Information technology to the rescue! [J].

Augen J. .

Nature Biotechnology, 2001, 19 (Suppl 6) :BE39-BE40

[4] The universal protein resource (UniProt) [J].

Bairoch, A ;

Apweiler, R ;

Wu, CH ;

Barker, WC ;

Boeckmann, B ;

Ferro, S ;

Gasteiger, E ;

Huang, HZ ;

Lopez, R ;

Magrane, M ;

Martin, MJ ;

Natale, DA ;

O'Donovan, C ;

Redaschi, N ;

Yeh, LSL .

NUCLEIC ACIDS RESEARCH, 2005, 33 :D154-D159

[5] The Protein Data Bank [J].

Berman, HM ;

Westbrook, J ;

Feng, Z ;

Gilliland, G ;

Bhat, TN ;

Weissig, H ;

Shindyalov, IN ;

Bourne, PE .

NUCLEIC ACIDS RESEARCH, 2000, 28 (01) :235-242

[6]

Bornberg-Bauer Erich, 2002, Brief Bioinform, V3, P166, DOI 10.1093/bib/3.2.166

[7] Will a biological database be different from a biological journal? [J].

Bourne, P .

PLOS COMPUTATIONAL BIOLOGY, 2005, 1 (03) :179-181

[8] Minimum information about a microarray experiment (MIAME) - toward standards for microarray data [J].

Brazma, A ;

Hingamp, P ;

Quackenbush, J ;

Sherlock, G ;

Spellman, P ;

Stoeckert, C ;

Aach, J ;

Ansorge, W ;

Ball, CA ;

Causton, HC ;

Gaasterland, T ;

Glenisson, P ;

Holstege, FCP ;

Kim, IF ;

Markowitz, V ;

Matese, JC ;

Parkinson, H ;

Robinson, A ;

Sarkans, U ;

Schulze-Kremer, S ;

Stewart, J ;

Taylor, R ;

Vilo, J ;

Vingron, M .

NATURE GENETICS, 2001, 29 (04) :365-371

[9] The Gene Ontology Annotation (GOA) Database: sharing knowledge in Uniprot with Gene Ontology [J].

Camon, E ;

Magrane, M ;

Barrell, D ;

Lee, V ;

Dimmer, E ;

Maslen, J ;

Binns, D ;

Harte, N ;

Lopez, R ;

Apweiler, R .

NUCLEIC ACIDS RESEARCH, 2004, 32 :D262-D266

[10]

CAREL R, 2003, PHARMAGENOMICS JUN, P22

← 1 2 3 4 5 6 7 →