Viral RNAs: Lessons from the Enemy

被引：34

作者：

Cullen, Bryan R. ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Ctr Virol, Durham, NC 27710 USA

来源：

CELL | 2009年 / 136卷 / 04期

关键词：

MESSENGER-RNA; NUCLEAR EXPORT; GENE-EXPRESSION; VIRUS GENOME; ENTRY SITE; HIV-1; TRANSLATION; INITIATION; MICRORNAS; CYTOPLASM;

D O I：

10.1016/j.cell.2009.01.048

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Viruses are adept at evolving or co-opting genomic elements that allow them to maximize their replication potential in the infected host. This evolutionary plasticity makes viruses an invaluable system to identify new mechanisms used not only by viruses but also by vertebrate cells to modulate gene expression. Here, I discuss the identification and characterization of viral mRNA structures and noncoding RNAs that have led to important insights into the molecular mechanisms of eukaryotic cells.

引用

页码：592 / 597

页数：6

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