Constitutive heterochromatin: a surprising variety of expressed sequences

被引：43

作者：

Dimitri, Patrizio ^{[1
,2
]}

Caizzi, Ruggiero ^{[3
]}

Giordano, Ennio ^{[4
]}

Accardo, Maria Carmela ^{[1
,2
]}

Lattanzi, Giovanna ^{[5
]}

Biamonti, Giuseppe ^{[6
]}

机构：

[1] Univ Roma La Sapienza, Lab Genom Funz & Prote Sistemi Modello, Dipartimento Genet & Biol Mol Charles Darwin, I-00185 Rome, Italy

[2] Univ Roma La Sapienza, Ist Pasteur, Dipartimento Genet & Biol Mol Charles Darwin, Fdn Bolognetti, I-00185 Rome, Italy

[3] Univ Bari, Dipartimento Genet & Microbiol, I-70126 Bari, Italy

[4] Univ Naples Federico II, Dipartimento Genet Biol Gen & Mol, I-80100 Naples, Italy

[5] IOR, Ist Genet Mol, Unit Bologna, I-40136 Bologna, Italy

[6] Ist Genet Mol, I-27100 Pavia, Italy

来源：

CHROMOSOMA | 2009年 / 118卷 / 04期

关键词：

DROSOPHILA-MELANOGASTER ENCODES; HUTCHINSON-GILFORD-PROGERIA; H3; LYSINE-9; METHYLATION; GENETIC-ANALYSIS; TRANSPOSABLE ELEMENTS; Y-CHROMOSOME; CENTROMERIC HETEROCHROMATIN; CENTRIC HETEROCHROMATIN; CYTOGENETIC ANALYSIS; NIPPED-B;

D O I：

10.1007/s00412-009-0211-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The organization of chromosomes into euchromatin and heterochromatin is amongst the most important and enigmatic aspects of genome evolution. Constitutive heterochromatin is a basic yet still poorly understood component of eukaryotic chromosomes, and its molecular characterization by means of standard genomic approaches is intrinsically difficult. Although recent evidence indicates that the presence of transcribed genes in constitutive heterochromatin is a conserved trait that accompanies the evolution of eukaryotic genomes, the term heterochromatin is still considered by many as synonymous of gene silencing. In this paper, we comprehensively review data that provide a clearer picture of transcribed sequences within constitutive heterochromatin, with a special emphasis on Drosophila and humans.

引用

页码：419 / 435

页数：17

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