Enzymatic preparation of an optically active precursor of the CC-1065/duocarmycin pharmacophore

被引：8

作者：

Chenevert, R

Courchesne, G

机构：

[1] Département de Chimie, Fac. des Sci. et de Genie, Université Laval, Québec

来源：

CHEMISTRY LETTERS | 1997年 / 01期

关键词：

D O I：

10.1246/cl.1997.11

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Acetylation of 2-[4-(benzyloxy)-2-nitrophenyl]propane-1,3-diol with vinyl acetate in the presence of porcine pancreatic lipase gave the (R)-mono-acetate (ee = 92%). The (S)-mono-acetate was obtained via acetylation of the diol followed by transesterification in ethanol in the presence of the same enzyme. Incorporation of these optically active mono-acetates into the established synthetic routes provided access to both enantiomers of the common pharmacophore of CC-1065/duocarmycin.

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页码：11 / 12

页数：2

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