Antimicrobial, antitumor and antileishmania screening of Medicinal Plants from Guinea-Bissau

被引：49

作者：

Abreu, PM ^{[1
]}

Martins, ES

Kayser, O

Bindseil, KU

Siems, K

Seemann, A

Freyert, J

机构：

[1] Univ Nova Lisboa, Fac Ciencias & Tecnol, Dept Quim, Ctr Quim Fina & Biotecnol, P-2825 Monte De Caparica, Portugal

[2] Inst Invest Cientif Trop, Ctr Bot, Lisbon, Portugal

[3] Free Univ Berlin, Inst Pharm 2, Berlin, Germany

[4] Analyticon AG, Potsdam, Germany

来源：

PHYTOMEDICINE | 1999年 / 6卷 / 03期

关键词：

medicinal plants; Guinea-Bissau; antimicrobial activity; antitumor activity; antileishmania activity;

D O I：

10.1016/S0944-7113(99)80008-7

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Following an ethnobotanical search carried out in Guinea-Bissau, eighteen extracts derived from sixteen medicinal species were screened for antimicrobial, antitumor and antileishmania activity. Significant antitumor activity was found for Holarrhena floribunda against KB (squamous carcinoma), SK-Mel 28 (melanoma), A 549 (lung carcinoma) and MDA-MB 231 (mamma carcinoma) cell lines, with corresponding IC50 values of 7.9, 9.0, 3.4 and 9.9 mu g/ml. Khaya senegalensis and Anthostema senegalense exhibited a significant activity against Leishmania donovani with IC50 values of 9.8 and 9.1 mu g/ml, respectively. Most of the extracts showed week or moderate antibacterial and antifungal activity, with MIC values in the range 0.25-1.0 mg/ml. Active extracts were submitted to bioassay-guided fractionation, and the IC50 and MIC of the active fractions were determined.

引用

页码：187 / 195

页数：9

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