Photoacoustic Imaging Guided Near-Infrared Photothermal Therapy Using Highly Water-Dispersible Single-Walled Carbon Nanohorns as Theranostic Agents

被引：194

作者：

Chen, Daiqin ^{[1
,2
]}

Wang, Chao ^{[3
]}

Nie, Xin ^{[4
,5
]}

Li, Shumu ^{[1
,2
]}

Li, Ruimin ^{[1
,2
]}

Guan, Mirong ^{[1
,2
]}

Liu, Zhuang ^{[3
]}

Chen, Chunying ^{[4
,5
]}

Wang, Chunru ^{[1
,2
]}

Shu, Chunying ^{[1
,2
]}

Wan, Lijun ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100190, Peoples R China

[2] Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China

[3] Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Jiangsu Key Lab Carbon Based Funct Mat & Devices, Suzhou 215123, Jiangsu, Peoples R China

[4] CAS Key Lab Biomed Effects Nanomat, Zhongguancun Beijing 100190, Peoples R China

[5] Nanosafety Natl Ctr Nanosci & Technol NCNST, Zhongguancun Beijing 100190, Peoples R China

来源：

ADVANCED FUNCTIONAL MATERIALS | 2014年 / 24卷 / 42期

基金：

中国国家自然科学基金;

关键词：

photoacoustic imaging; photothermal therapy; single-walled carbon nanohorns; theranostics; NANOTUBES; TOMOGRAPHY; NANOMATERIALS; GRAPHENE; SIZE;

D O I：

10.1002/adfm.201401560

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

The poly(maleic anhydride-alt-1-octadecene-poly(ethylene glycol)) (C18PMH-PEG) modified single-walled carbon nanohorns (SWNHs) are designed with high stability and biocompatibility. The as-prepared SWNHs/C18PMH-PEG not only can serve as an excellent photothermal agent but also can be used as a promising photoacoustic imaging (PAI) agent both in vitro and in vivo due to its strong absorption in the near infrared (NIR) region. The PAI result reveals that the SWNHs/C18PMH-PEG possesses ultra long blood circulation time and can significantly be accumulated at the tumor site through the enhanced penetration and retention (EPR) effect. The maximum accumulation of SWNHs/C18PMH-PEG at tumor site could be achieved at the time point of 24 h after intravenous injection, which is considered to be the optimal time for the 808 nm laser treatment. The subsequent photothermal ablation of tumors can be achieved without triggering any side effects. Therefore, a PAI guided PTT platform based on SWNHs is proposed and highlights the potential theranostic application for biomedical uses.

引用

页码：6621 / 6628

页数：8

共 45 条

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