A tale of early response genes

被引：57

作者：

Sng, JCG ^{[1
]}

Taniura, H ^{[1
]}

Yoneda, Y ^{[1
]}

机构：

[1] Kanazawa Univ, Grad Sch Nat Sci & Technol, Mol Pharmacol Lab, Kanazawa, Ishikawa 9201192, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2004年 / 27卷 / 05期

关键词：

histone modification; chromatin remodeling enzyme; immediate early gene; c-fos; c-jun; transcriptional regulation;

D O I：

10.1248/bpb.27.606

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Immediate early genes (IEG) are rapidly but transiently induced directly by intracellular signaling cascades to alter patterns of gene expression. It has been proposed that histone modifications could be the key to the quick alteration of chromatin structure, as this spread occurs too rapidly to be the consequence of passage of RNA polymerase II. In this review, we will discuss the different modifications on histones and the chromatin remodeling enzymes, allowing the promoter regions of two IEGs, c-fos and e-jun, to be accessed.

引用

页码：606 / 612

页数：7

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