New potent and selective A1 adenosine receptor agonists

被引:18
作者
Hutchinson, SA
Baker, SP
Linden, J
Scammells, PJ [1 ]
机构
[1] Deakin Univ, Sch Biol & Chem Sci, Geelong, Vic 3217, Australia
[2] Monash Univ, Victorian Coll Pharm, Dept Med Chem, Parkville, Vic 3052, Australia
[3] Univ Florida, Coll Med, Dept Pharmacol & Therapeut, Gainesville, FL 32610 USA
[4] Univ Virginia, Dept Med Cardiol, Charlottesville, VA 22908 USA
[5] Univ Virginia, Dept Mol Physiol & Biol Phys, Charlottesville, VA 22908 USA
关键词
adenosine; agonist; A(1); adenosine receptor (A(1)AR);
D O I
10.1016/j.bmc.2004.07.004
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Thiirane analogs of ENAdo have been synthesised and found to be extremely potent and selective A I adenosine receptor agonists. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:4877 / 4884
页数:8
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