A Copper-Catalyzed Tandem Synthesis of Indolo- and Pyrrolo[2,1-a]isoquinolines

被引：219

作者：

Verma, Akhilesh Kumar ^{[1
]}

Kesharwani, Tanay ^{[2
]}

Singh, Jaspal ^{[1
]}

Tandon, Vibha ^{[1
]}

Larock, Richard C. ^{[2
]}

机构：

[1] Univ Delhi, Dr BR Ambedkar Ctr Biomed Res, Delhi 110007, India

[2] Iowa State Univ Sci & Technol, Dept Chem, Ames, IA 50011 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 06期

关键词：

alkynes; benzotriazoles; C-C coupling; copper; cyclization; ELECTROPHILIC CYCLIZATION; EFFICIENT SYNTHESIS; POLYCYCLIC AROMATICS; DOMINO REACTIONS; ARYL HALIDES; N-ARYLATION; ALKYNES; BOND; 2-(1-ALKYNYL)-2-ALKEN-1-ONES; CYCLOISOMERIZATION;

D O I：

10.1002/anie.200804427

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Isoquinoline ring the changes: A novel strategy for the title reaction involves ortho-haloarylalkynes which undergo sequential intermolecular addition of N heterocycles onto alkynes and subsequent intramolecular ring closure by arylation. The process involves the use of hydroxymethyl benzotriazole as an efficient and inexpensive ligand for the C - N and C - C coupling reactions. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：1138 / 1143

页数：6

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