Different approaches to understanding autoimmune rheumatic diseases: the neuroimmunoendocrine system

被引：12

作者：

Butts, CL ^{[1
]}

Sternberg, EM ^{[1
]}

机构：

[1] NIMH, Bethesda, MD 20892 USA

来源：

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY | 2004年 / 18卷 / 02期

关键词：

neuroendocrine; hormones and immunity;

D O I：

10.1016/j.berh.2004.02.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rheumatic autoimmune diseases are characterized by dysregulation of the immune response that leads to inflammation, pain, disease and stiffness and have been shown to have differences in disease pattern, depending on the gender and age of an individual. The majority of these conditions predominantly affect females of all species and also show increased severity of disease in female animal models. In addition to the gender differences in disease development, persons are often more susceptible at specific stages of life. This review will discuss some of the data indicating age and gender differences in development of these diseases and will review hormonal and other factors that may contribute to disease expression and severity.

引用

页码：125 / 139

页数：15

共 61 条

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