Cytomegalovirus infections and anti-GM2 antibodies in Guillain-Barre syndrome

被引：79

作者：

Jacobs, BC

vanDoorn, PA

Groeneveld, JHM

TioGillen, AP

vanderMeche, FGA

机构：

[1] UNIV HOSP DIJKZIGT,DEPT IMMUNOL,NL-3015 GD ROTTERDAM,NETHERLANDS

[2] ERASMUS UNIV ROTTERDAM,ROTTERDAM,NETHERLANDS

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1997年 / 62卷 / 06期

关键词：

Guillain-Barre syndrome; anti-GM2; antibodies; cytomegalovirus;

D O I：

10.1136/jnnp.62.6.641

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To investigate whether antecedent cytomegalovirus (CMV) infections in patients with Guillain-Barre syndrome are associated with the presence of specific antiganglioside antibodies, acute phase serum samples from 130 patients with Guillain-Barre syndrome and 200 controls were tested. Anti-GM2 IgM antibodies were found more often in patients with Guillain-Barre syndrome with CMV infection (22%) than in patients without the infection (2%) (P = 0.003). CMV infections may elicit anti-GM2 antibodies in susceptible patients, which may contribute to the pathogenesis of Guillain-Barre syndrome associated with CMV.

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页码：641 / 643

页数：3

相关论文

共 14 条

[1] CHEMICAL STRUCTURES OF THE CORE REGIONS OF CAMPYLOBACTER-JEJUNI SEROTYPES O-1, O-4, O-23, AND O-36 LIPOPOLYSACCHARIDES [J].

ASPINALL, GO ;

MCDONALD, AG ;

RAJU, TS ;

PANG, H ;

MORAN, AP ;

PENNER, JL .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1993, 213 (03) :1017-1027

[2] SURAL NERVE BIOPSIES IN GUILLAIN-BARRE-SYNDROME - AXONAL DEGENERATION AND MACROPHAGE-ASSOCIATED DEMYELINATION AND ABSENCE OF CYTOMEGALOVIRUS GENOME [J].

HUGHES, R ;

ATKINSON, P ;

COATES, P ;

HALL, S ;

LEIBOWITZ, S .

MUSCLE & NERVE, 1992, 15 (05) :568-575

[3] ANTI-GM1 IGA ANTIBODIES IN GUILLAIN-BARRE-SYNDROME [J].

ILYAS, AA ;

MITHEN, FA ;

CHEN, ZW ;

COOK, SD .

JOURNAL OF NEUROIMMUNOLOGY, 1992, 36 (01) :69-76

[4] Association of anti-GM(2) antibodies in Guillain-Barre syndrome with acute cytomegalovirus infection [J].

Irie, S ;

Saito, T ;

Nakamura, K ;

Kanazawa, N ;

Ogino, M ;

Nukazawa, T ;

Ito, H ;

Tamai, Y ;

Kowa, H .

JOURNAL OF NEUROIMMUNOLOGY, 1996, 68 (1-2) :19-26

[5] Campylobacter jejuni infections and anti-GM1 antibodies in Guillain-Barre syndrome [J].

Jacobs, BC ;

vanDoorn, PA ;

Schmitz, PIM ;

TioGillen, AP ;

Herbrink, P ;

Visser, LH ;

Hooijkaas, H ;

vanderMeche, FGA .

ANNALS OF NEUROLOGY, 1996, 40 (02) :181-187

[6] ANTI-GAL-C ANTIBODY IN AUTOIMMUNE NEUROPATHIES SUBSEQUENT TO MYCOPLASMA-INFECTION [J].

KUSUNOKI, S ;

CHIBA, A ;

HITOSHI, S ;

TAKIZAWA, H ;

KANAZAWA, I .

MUSCLE & NERVE, 1995, 18 (04) :409-413

[7] ANTIGANGLIOSIDE GM(1) ANTIBODIES IN GUILLAIN-BARRE-SYNDROME AND THEIR RELATIONSHIP TO CAMPYLOBACTER-JEJUNI INFECTION [J].

REES, JH ;

GREGSON, NA ;

HUGHES, RAC .

ANNALS OF NEUROLOGY, 1995, 38 (05) :809-816

[8] ANTIBODY DETECTION IN GUILLAIN-BARRE-SYNDROME [J].

SVENNERHOLM, L ;

FREDMAN, P .

ANNALS OF NEUROLOGY, 1990, 27 :S36-S40

[9]

Van Der Meche F. G. A., 1995, Annals of Neurology, V37, pS14

[10] A RANDOMIZED TRIAL COMPARING INTRAVENOUS IMMUNE GLOBULIN AND PLASMA-EXCHANGE IN GUILLAIN-BARRE-SYNDROME [J].

VANDERMECHE, FGA ;

SCHMITZ, PIM .

NEW ENGLAND JOURNAL OF MEDICINE, 1992, 326 (17) :1123-1129