Impact of nano- and mesoscale particles on the performance of microcantilever-based sensors

被引:8
作者
Bottomley, LA [1 ]
Poggi, MA
Shen, SX
机构
[1] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA
[2] Protiveris Inc, Rockville, MD 20850 USA
关键词
D O I
10.1021/ac049111x
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Microcantilever-based sensors comprise an emerging class of chemomechanical sensors. The crucial challenge for every new and promising sensing platform lies in its performance in complex mixtures. Since most biofluids are rich in particulates, we assessed the impact of particles in the liquid stream on the performance of microcantilever sensors operated in both deflection and resonance modes. For both detection modes, sensor response depends on the particle diameter, concentration, and velocity as well as the composition of a thin-film coating. The presence of particles in the fluid stream produce substantial scattering of the laser beam used to measure cantilever deflection. Thus, prior removal of particulate matter from biofluids is required for optimal performance of microcantilever-based biosensors.
引用
收藏
页码:5685 / 5689
页数:5
相关论文
共 38 条
  • [1] A cantilever array-based artificial nose
    Baller, MK
    Lang, HP
    Fritz, J
    Gerber, C
    Gimzewski, JK
    Drechsler, U
    Rothuizen, H
    Despont, M
    Vettiger, P
    Battiston, FM
    Ramseyer, JP
    Fornaro, P
    Meyer, E
    Güntherodt, HJ
    [J]. ULTRAMICROSCOPY, 2000, 82 (1-4) : 1 - 9
  • [2] PHOTOTHERMAL SPECTROSCOPY WITH FEMTOJOULE SENSITIVITY USING A MICROMECHANICAL DEVICE
    BARNES, JR
    STEPHENSON, RJ
    WELLAND, ME
    GERBER, C
    GIMZEWSKI, JK
    [J]. NATURE, 1994, 372 (6501) : 79 - 81
  • [3] ADSORPTION-INDUCED SURFACE STRESS AND ITS EFFECTS ON RESONANCE FREQUENCY OF MICROCANTILEVERS
    CHEN, GY
    THUNDAT, T
    WACHTER, EA
    WARMACK, RJ
    [J]. JOURNAL OF APPLIED PHYSICS, 1995, 77 (08) : 3618 - 3622
  • [4] Enantioselective sensors based on antibody-mediated nanomechanics
    Dutta, P
    Tipple, CA
    Lavrik, NV
    Datskos, PG
    Hofstetter, H
    Hofstetter, O
    Sepaniak, MJ
    [J]. ANALYTICAL CHEMISTRY, 2003, 75 (10) : 2342 - 2348
  • [5] Translating biomolecular recognition into nanomechanics
    Fritz, J
    Baller, MK
    Lang, HP
    Rothuizen, H
    Vettiger, P
    Meyer, E
    Güntherodt, HJ
    Gerber, C
    Gimzewski, JK
    [J]. SCIENCE, 2000, 288 (5464) : 316 - 318
  • [6] Stress at the solid-liquid interface of self-assembled monolayers on gold investigated with a nanomechanical sensor
    Fritz, J
    Baller, MK
    Lang, HP
    Strunz, T
    Meyer, E
    Güntherodt, HJ
    Delamarche, E
    Gerber, C
    Gimzewski, JK
    [J]. LANGMUIR, 2000, 16 (25) : 9694 - 9696
  • [7] KINETICS OF POLYSTYRENE ADSORPTION ONTO GOLD FROM DILUTE THETA SOLUTIONS
    FU, TZ
    STIMMING, U
    DURNING, CJ
    [J]. MACROMOLECULES, 1993, 26 (13) : 3271 - 3281
  • [8] OBSERVATION OF A CHEMICAL-REACTION USING A MICROMECHANICAL SENSOR
    GIMZEWSKI, JK
    GERBER, C
    MEYER, E
    SCHLITTLER, RR
    [J]. CHEMICAL PHYSICS LETTERS, 1994, 217 (5-6) : 589 - 594
  • [9] Characterisation of an antibody coated microcantilever as a potential immuno-based biosensor
    Grogan, C
    Raiteri, R
    O'Connor, GM
    Glynn, TJ
    Cunningham, V
    Kane, M
    Charlton, M
    Leech, D
    [J]. BIOSENSORS & BIOELECTRONICS, 2002, 17 (03) : 201 - 207
  • [10] Cantilever-based optical deflection assay for discrimination of DNA single-nucleotide mismatches
    Hansen, KM
    Ji, HF
    Wu, GH
    Datar, R
    Cote, R
    Majumdar, A
    Thundat, T
    [J]. ANALYTICAL CHEMISTRY, 2001, 73 (07) : 1567 - 1571