Dependence of chiral separations on the amount of cyclodextrins as selectors, employing the partial filling technique in capillary zone electrophoresis

The enantioselectivity, resolution factor and migration times for some local anaesthetic drugs were evaluated at different selector concentrations and plug lengths with different cyclodextrins as chiral selectors using the partial filling technique. The resolution remained constant when equal amounts of the chiral selector at a concentration below the optimal concentration were introduced in the capillary. However, the selectivity factor increased with increasing concentration of the chiral selector.