Lipophilic bis-arylsulfonates as inhibitors of the CD4-gp120 interaction

被引：8

作者：

Patch, RJ

Roberts, JC

Gao, H

Shi, Z

Gopalsamy, A

Kongsjahju, A

Daniels, K

Kowalczyk, PJ

vanSchravendijk, MR

Gordon, KA

Pallai, PV

机构：

[1] PROCEPT INC,DEPT PROT BIOCHEM,CAMBRIDGE,MA 02139

[2] PROCEPT INC,DEPT IMMUNOL,CAMBRIDGE,MA 02139

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 24期

关键词：

D O I：

10.1016/S0960-894X(96)00552-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of lipophilic bis-arylsulfonates was synthesized and evaluated as potential inhibitors of the CD4-gp120 interaction. Structure-activity studies suggested a direct relationship between the nature and extent of lipophilicity and inhibitory potency. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2983 / 2988

页数：6

共 17 条

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ROBERTS JC, 1996, IN PRESS TETRAHEDRON

[12] MEDIATION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 BINDING BY INTERACTION OF CELL-SURFACE HEPARAN-SULFATE PROTEOGLYCANS WITH THE V3 REGION OF ENVELOPE GP120-GP41 [J].