The enantioselective synthesis of α-amino acid derivatives via organoboranes

被引：26

作者：

O'Donnell, MJ ^{[1
]}

Drew, MD ^{[1
]}

Cooper, JT ^{[1
]}

Delgado, F ^{[1
]}

Zhou, CY ^{[1
]}

机构：

[1] Indiana Univ Purdue Univ, Dept Chem, Indianapolis, IN 46202 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 32期

关键词：

D O I：

10.1021/ja017522e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Optically active (S)-α-amino acids are prepared in 54-95% ee (12 cases) by reaction of the Schiff base acetate of glycine tert-butyl ester with B-alkyl-9-BBN derivatives in the presence of the Cinchona alkaloid, cinchonidine, and base. The enantiomeric (R)-α-amino acids are available in 59-92% ee (3 cases) by using cinchonine as the chiral control element. Copyright © 2002 American Chemical Society.

引用

页码：9348 / 9349

页数：2

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