Integrated multi-sensor chip with photocured polymer membranes containing copolymerised plasticizer for direct pH, potassium, sodium and chloride ions determination in blood serum

被引：16

作者：

Abramova, Natalia ^{[1
]}

Ipatov, Andrey ^{[1
]}

Levichev, Sergey ^{[2
]}

Bratov, Andrey ^{[1
]}

机构：

[1] CSIC, Ctr Nacl Microelect, Inst Microelect, Chem Transducers Grp, E-08193 Barcelona, Spain

[2] St Petersburg State Univ, Chem Sensors Lab, Fac Chem, St Petersburg 199034, Russia

来源：

TALANTA | 2009年 / 79卷 / 04期

关键词：

ISFET sensor array; Photocured polymer membranes; Sequential injection analysis; Blood analysis; SELECTIVE ELECTRODES; INJECTION-ANALYSIS; ANIONIC SITES; CHEMICAL SENSORS; TECHNOLOGY; IONOPHORES; MATRIX; VALVE; SIA;

D O I：

10.1016/j.talanta.2009.03.023

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

An analytical system based on a sensor array with ion-selective field effect transistors (ISFETs) monolithically integrated in one chip covered with photocured polymer membranes containing copolymerised plasticizer and a sequential injection analysis (SIA) is shown to offer an automation of the analysis of blood serum components. For sequential injection system a custom made dual channel flow cell for the sensor array was developed. Optimisation of ion-sensitive membrane characteristics and calibration solution compositions were carried out. The system was used to analyze sodium, potassium, chloride ion contents in blood serum samples. The precision of the ion determination in samples was typical for potentiometic method with standard deviation of about 3-5%. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：984 / 989

页数：6

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