Genomic-scale gene expression analysis of lymphocyte growth, tolerance and malignancy

被引:20
作者
Glynne, RJ
Ghandour, G
Goodnow, CC
机构
[1] Eos Biotechnol, S San Francisco, CA 94080 USA
[2] Australian Natl Univ, John Curtin Sch Med Res, Med Genome Ctr, Canberra, ACT 2601, Australia
关键词
D O I
10.1016/S0952-7915(99)00076-X
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Immunologists are already comfortable with the need for monitoring many different gene products simultaneously. It is a common challenge to remember what CD-one-hundred-and-something is, and an ever-increasing number of colours are required for identification on the flow cytometer. Gene expression arrays now offer the possibility of extending this approach beyond the cell surface and expanding it dramatically to survey the entire catalogue of gene transcripts in a lymphoid cell.
引用
收藏
页码:210 / 214
页数:5
相关论文
共 24 条
[11]   Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring [J].
Golub, TR ;
Slonim, DK ;
Tamayo, P ;
Huard, C ;
Gaasenbeek, M ;
Mesirov, JP ;
Coller, H ;
Loh, ML ;
Downing, JR ;
Caligiuri, MA ;
Bloomfield, CD ;
Lander, ES .
SCIENCE, 1999, 286 (5439) :531-537
[12]   Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis [J].
Grumont, RJ ;
Rourke, IJ ;
Gerondakis, S .
GENES & DEVELOPMENT, 1999, 13 (04) :400-411
[13]   The transcriptional program in the response of human fibroblasts to serum [J].
Iyer, VR ;
Eisen, MB ;
Ross, DT ;
Schuler, G ;
Moore, T ;
Lee, JCF ;
Trent, JM ;
Staudt, LM ;
Hudson, J ;
Boguski, MS ;
Lashkari, D ;
Shalon, D ;
Botstein, D ;
Brown, PO .
SCIENCE, 1999, 283 (5398) :83-87
[14]   Gene expression profiles of laser-captured adjacent neuronal subtypes [J].
Luo, L ;
Salunga, RC ;
Guo, HQ ;
Bittner, A ;
Joy, KC ;
Galindo, JE ;
Xiao, HN ;
Rogers, KE ;
Wan, JS ;
Jackson, MR ;
Erlander, MG .
NATURE MEDICINE, 1999, 5 (01) :117-122
[15]   Evolutionary parameters of the transcribed mammalian genome: An analysis of 2,820 orthologous rodent and human sequences [J].
Makalowski, W ;
Boguski, MS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (16) :9407-9412
[16]   The promise of comparative genomics in mammals [J].
O'Brien, SJ ;
Menotti-Raymond, M ;
Murphy, WJ ;
Nash, WG ;
Wienberg, J ;
Stanyon, R ;
Copeland, NG ;
Jenkins, NA ;
Womack, JE ;
Graves, JAM .
SCIENCE, 1999, 286 (5439) :458-+
[17]   LIGHT-GENERATED OLIGONUCLEOTIDE ARRAYS FOR RAPID DNA-SEQUENCE ANALYSIS [J].
PEASE, AC ;
SOLAS, D ;
SULLIVAN, EJ ;
CRONIN, MT ;
HOLMES, CP ;
FODOR, SPA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (11) :5022-5026
[18]   QUANTITATIVE MONITORING OF GENE-EXPRESSION PATTERNS WITH A COMPLEMENTARY-DNA MICROARRAY [J].
SCHENA, M ;
SHALON, D ;
DAVIS, RW ;
BROWN, PO .
SCIENCE, 1995, 270 (5235) :467-470
[19]   Rapid on/off cycling of cytokine production by virus-specific CD8+ T cells [J].
Slifka, MK ;
Rodriguez, F ;
Whitton, JL .
NATURE, 1999, 401 (6748) :76-79
[20]   DETECTION OF SPECIFIC SEQUENCES AMONG DNA FRAGMENTS SEPARATED BY GEL-ELECTROPHORESIS [J].
SOUTHERN, EM .
JOURNAL OF MOLECULAR BIOLOGY, 1975, 98 (03) :503-+