In Vivo Selection of Reduced Susceptibility to Carbapenems in Acinetobacter baumannii Related to ISAba1-Mediated Overexpression of the Natural blaOXA-66 Oxacillinase Gene

被引：68

作者：

Figueiredo, Samy ^{[1
,2
]}

Poirel, Laurent ^{[1
,2
]}

Croize, Jacques ^{[3
]}

Recule, Christine ^{[3
]}

Nordmann, Patrice ^{[1
,2
]}

机构：

[1] Hop Bicetre, AP HP, Serv Bacteriol Virol,Fac Med, INSERM,U Emerging Resistance Antibiot 914, K Bicetre, France

[2] Univ Paris 11, K Bicetre, France

[3] DAI Pol Biol, Dept Bacteriol Microbiovigilance, Grenoble, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 06期

关键词：

HYDROLYZING OXACILLINASES; RESISTANCE; ISABA1; EXPRESSION; EMERGENCE; INSERTION; OUTBREAK;

D O I：

10.1128/AAC.01663-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Two clonally related Acinetobacter baumannii isolates, A1 and A2, were obtained from the same patient. Isolate A2, selected after an imipenem-containing treatment, showed reduced susceptibility to carbapenems. This resistance pattern was related to insertion of the ISAba1 element upstream of the naturally occurring bla(OXA-66) carbapenemase gene as demonstrated by sequencing, reverse transcription-PCR analysis, and inactivation of the bla(OXA-66) gene.

引用

页码：2657 / 2659

页数：3

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