Regulatory T Cell Immunotherapy for Type 1 Diabetes: A Step Closer to Success?

被引：34

作者：

Bayry, Jagadeesh ^{[1
,2
,3
,4
]}

Gautier, Jean-Francois ^{[1
,2
,3
,5
,6
]}

机构：

[1] INSERM, Unite 1138, F-75006 Paris, France

[2] Univ Paris 06, Sorbonne Univ, UMR S 1138, F-75006 Paris, France

[3] Univ Paris 05, Sorbonne Paris Cite, UMR S 1138, F-75006 Paris, France

[4] Ctr Rech Cordeliers, Equipe Immunopathol & Immunointervent Therapeut, F-75006 Paris, France

[5] Ctr Rech Cordeliers, Equipe Pathogenese Cellulaire & Clin Diabete, F-75006 Paris, France

[6] Univ Paris 07, Ctr Univ Diabete & Ses Complicat, Hop Lariboisiere, Serv Diabetol Endocrinol Nutr, F-75010 Paris, France

来源：

CELL METABOLISM | 2016年 / 23卷 / 02期

关键词：

D O I：

10.1016/j.cmet.2016.01.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Regulatory T cell (Treg) therapy has shown promises in experimental models of type 1 diabetes (T1D) and other autoimmune diseases. Now, Bluestone et al. (2015) report in a phase 1, dose-escalation study that ex vivo-expanded autologous polyclonal Treg therapy is safe and well tolerated in adult patients with recent-onset T1D.

引用

页码：231 / 233

页数：3

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