Desorption electrospray ionization using an Orbitrap mass spectrometer: exact mass measurements on drugs and peptides

被引:46
作者
Hu, Qizhi [1 ]
Talaty, Nari [1 ]
Noll, Robert J. [1 ]
Cooks, R. Graham [1 ]
机构
[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA
关键词
D O I
10.1002/rcm.2757
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Desorption electrospray ionization (DESI) is implemented on an Orbitrap mass spectrometer. The ion source is described and applications which utilize the high-resolution capabilities of the Orbitrap are emphasized, including the characterization of peptides and active ingredients in pharmaceutical tablets. Measurements are made in less than 1s at a resolution of 60 000. The implications of the data for the mechanisms of DESI are discussed. Copyright (c) 2006 John Wiley & Sons, Ltd.
引用
收藏
页码:3403 / 3408
页数:6
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