Compositional and Functional Features of the Gastrointestinal Microbiome and Their Effects on Human Health

被引：499

作者：

Hollister, Emily B. ^{[1
,3
]}

Gao, Chunxu ^{[1
,2
,3
]}

Versalovic, James ^{[1
,2
,3
]}

机构：

[1] Baylor Coll Med, Dept Pathol & Immunol, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA

[3] Texas Childrens Hosp, Dept Pathol, Houston, TX 77030 USA

来源：

GASTROENTEROLOGY | 2014年 / 146卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Gastrointestinal; HMP; Lumen; Metagenomics; Microbe; Mucosa; HUMAN GUT MICROBIOME; INTESTINAL MICROBIOTA; DISTAL ESOPHAGUS; PHAGE THERAPY; BACTERIA; DISEASE; TRACT; DIVERSITY; AGE; ANTIBIOTICS;

D O I：

10.1053/j.gastro.2014.01.052

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

The human gastrointestinal tract contains distinct microbial communities that differ in composition and function based on their location, as well as age, sex, race/ethnicity, and diet of their host. We describe the bacterial taxa present in different locations of the GI tract, and their specific metabolic features. The distinct features of these specific microbial communities might affect human health and disease. Several bacterial taxa and metabolic modules (biochemical functions) have been associated with human health and the absence of disease. Core features of the healthy microbiome might be defined and targeted to prevent disease and optimize human health.

引用

页码：1449 / 1458

页数：10

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