Self-immolative dendrimer biodegradability by multi-enzymatic triggering

被引：67

作者：

Amir, RJ ^{[1
]}

Shabat, D ^{[1
]}

机构：

[1] Tel Aviv Univ, Raymond & Beverly Sackler Fac Exact Sci, Sch Chem, IL-69978 Tel Aviv, Israel

来源：

CHEMICAL COMMUNICATIONS | 2004年 / 14期

关键词：

D O I：

10.1039/b404946b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New self-immolative dendritic molecules have been designed and synthesized. The dendrons are built with a multi-enzymatic triggering mechanism, which initiates their biodegradation through a self-immolative chain fragmentation to release a reporter group from the focal point. The dendritic backbone is constructed from polycarbamate linkages, which are stable to hydrolysis and enhance the dendrons' solubility in water. The degradation can readily take place under physiological conditions on enzymatic triggering.

引用

页码：1614 / 1615

页数：2

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