Click to chelate:: Synthesis and installation of metal chelates into biomolecules in a single step

被引：293

作者：

Mindt, Thomas L.

Struthers, Harriet

Brans, Luc

Anguelov, Todor

Schweinsberg, Christian

Maes, Veronique

Tourwe, Dirk

Schibli, Roger ^{[1
]}

机构：

[1] ETH, Dept Chem & Appl Biosci, CH-8093 Zurich, Switzerland

[2] ETH, Paul Scherrer Inst, Ctr Radiopharmaceut Sci, USZ, CH-5232 Villigen, Switzerland

[3] Free Univ Brussels, Fac Sci, B-1050 Brussels, Belgium

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 47期

关键词：

D O I：

10.1021/ja066779f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Click chemistry has been employed for the assembly of novel and efficient triazole-based multidentate chelating systems while simultaneously attaching them to molecules of biological interest. The click-to-chelate" approach offers a powerful new tool for the modification of (bio)molecules with metal chelators for potential diagnostic and therapeutic applications. Copyright © 2006 American Chemical Society."

引用

收藏

页码：15096 / 15097

页数：2

相关论文

共 24 条

[1] New organometallic technetium complexes for radiopharmaceutical imaging [J].

Alberto, R .

CONTRAST AGENTS III: RADIOPHARMACEUTICALS - FROM DIAGNOSTICS TO THERAPEUTICS, 2005, 252 :1-44

[2] A novel organometallic aqua complex of technetium for the labeling of biomolecules:: Synthesis of [99mTc(OH2)3(CO)3]+ from [99mTcO4]- in aqueous solution and its reaction with a bifunctional ligand [J].

Alberto, R ;

Schibli, R ;

Egli, A ;

Schubiger, AP ;

Abram, U ;

Kaden, TA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (31) :7987-7988

[3] New directions in the coordination chemistry of 99mTc:: a reflection on technetium core structures and a strategy for new chelate design [J].

Banerjee, SR ;

Maresca, KP ;

Francesconi, L ;

Valliant, J ;

Babich, JW ;

Zubieta, J .

NUCLEAR MEDICINE AND BIOLOGY, 2005, 32 (01) :1-20

[4] Polytriazoles as copper(I)-stabilizing ligands in catalysis [J].

Chan, TR ;

Hilgraf, R ;

Sharpless, KB ;

Fokin, VV .

ORGANIC LETTERS, 2004, 6 (17) :2853-2855

[5] Triazole-based monophosphine ligands for palladium-catalyzed cross-coupling reactions of aryl chlorides [J].

Dai, Q ;

Gao, WZ ;

Liu, D ;

Kapes, LM ;

Zhang, XM .

JOURNAL OF ORGANIC CHEMISTRY, 2006, 71 (10) :3928-3934

[6] Functionalization of glucose at position C-3 for transition metal coordination: Organo-rhenium complexes with carbohydrate skeletons [J].

Dumas, C ;

Petrig, J ;

Frei, L ;

Spingler, B ;

Schibli, R .

BIOCONJUGATE CHEMISTRY, 2005, 16 (02) :421-428

[7]

GARCIAGARAYOA E, 2006, IN PRESS NUCL MED BI

[8] Expedient synthesis of triazole-linked glycosyl amino acids and peptides [J].

Kuijpers, BHM ;

Groothuys, S ;

Keereweer, AR ;

Quaedflieg, PJLM ;

Blaauw, RH ;

van Delft, FL ;

Rutjes, FPJT .

ORGANIC LETTERS, 2004, 6 (18) :3123-3126

[9] Direct reductive alkylation of amino acids: Synthesis of bifunctional chelates for nuclear imaging [J].

Levadala, MK ;

Banerjee, SR ;

Maresca, KP ;

Babich, JW ;

Zubieta, J .

SYNTHESIS-STUTTGART, 2004, (11) :1759-1766

[10] Presentation and detection of azide functionality in bacterial cell surface proteins [J].

Link, AJ ;

Vink, MKS ;

Tirrell, DA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (34) :10598-10602