Carrageenans: Biological properties, chemical modifications and structural analysis - A review

被引：874

作者：

Campo, Vanessa Leiria ^{[1
]}

Kawano, Daniel Fabio ^{[1
]}

da Silva, Dilson Braz, Jr. ^{[1
]}

Carvalho, Ivone ^{[1
]}

机构：

[1] Univ Sao Paulo, Dept Ciencias Farmaceut, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040930 Ribeirao Preto, SP, Brazil

来源：

CARBOHYDRATE POLYMERS | 2009年 / 77卷 / 02期

关键词：

Carrageenans; Biological activities; Chemical modification; Structural analysis; IONIZATION-MASS-SPECTROMETRY; SIZE-EXCLUSION CHROMATOGRAPHY; MOLECULAR-WEIGHT CARRAGEENANS; LASER-DESORPTION IONIZATION; SIMPLEX-VIRUS-INFECTION; IN-VIVO ANTITUMOR; ANTI-HIV ACTIVITY; KAPPA-CARRAGEENAN; IOTA-CARRAGEENAN; LIQUID-CHROMATOGRAPHY;

D O I：

10.1016/j.carbpol.2009.01.020

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Carrageenans are sulphated linear polysaccharicles Of D-galactose and 3,6-anhydro-D-galactose extracted from certain red seaweeds of the Rhodophyceae class. They have been extensively used in the food industry as thickening, gelling and protein-suspending agents, and more recently by the pharmaceutical industry as excipient in pills and tablets. Besides the well-known biological activities related to inflammatory and immune responses, carrageenans are potent inhibitors of herpes and HPV viruses and there are indications that these polysaccharicles may offer some protection against HIV infection. Thus, this review describes important aspects of carrageenans related to their industrial/therapeutic applications, physicochemical properties and structural analysis. Moreover, chemical modifications of carrageenans that can lead to prototypes with potential application for the treatment of several diseases, such as herpes, HPV and AIDS, will be outlined. (c) 2009 Elsevier Ltd. All rights reserved.

引用

页码：167 / 180

页数：14

共 148 条

[81]

Koswig S., 1997, Seminars in Food Analysis, V2, P71

[82] Analysis of heparan sulfate oligosaccharides with ion pair-reverse phase capillary high performance liquid chromatography-microelectrospray ionization time-of-flight mass spectrometry [J].