Interleukin-17 and systemic lupus erythematosus: current concepts

被引:167
作者
Nalbandian, A. [1 ]
Crispin, J. C. [1 ]
Tsokos, G. C. [1 ]
机构
[1] Harvard Univ, Sch Med, Div Rheumatol, Beth Israel Deaconess Med Ctr,Dept Med, Boston, MA 02215 USA
基金
美国国家卫生研究院;
关键词
autoimmunity; DN T cells; IL-17; SLE; Th17; REGULATORY T-CELLS; GROWTH-FACTOR-BETA; COLONY-STIMULATING FACTOR; ROR-GAMMA-T; AUTOIMMUNE INFLAMMATION; CHEMOKINE PRODUCTION; HELPER-CELLS; HOST-DEFENSE; TH17; CELLS; PROINFLAMMATORY CYTOKINES;
D O I
10.1111/j.1365-2249.2009.03944.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The emerging role of interleukin (IL)-17 as a hallmark proinflammatory cytokine of the adaptive immune system, produced primarily by a new T helper cell subset termed 'Th17', has received considerable attention. Differentiation of Th17 cells is driven by the simultaneous presence of transforming growth factor-beta and certain inflammatory cytokines (e.g. IL-6, IL-21), and recent studies have shown that inflammation instigated by IL-17-producing cells is central to the development and pathogenesis of several human autoimmune diseases and animal models of autoimmunity. In this review, we focus on the information regarding IL-17 and systemic lupus erythematosus (SLE), a chronic autoimmune disease. The work that has explored the development and behaviour of IL-17-producing cells in SLE is discussed, and different mechanisms by which IL-17 could potentially augment inflammation and autoantibody production in the context of SLE are proposed.
引用
收藏
页码:209 / 215
页数:7
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