Identification of subgroups in amnestic mild cognitive impairment

被引:44
作者
Guedj, E. [1 ]
Barbeau, E. J.
Didic, M.
Felician, O.
de Laforte, C.
Ceccaldi, M.
Mundler, O.
Poncet, M.
机构
[1] CHU Timone, Assistance Publ Hop Marseille, Serv Cent Biophys & Med Nucl, 264 Rue St Pierre, F-13385 Marseille 5, France
[2] CNRS, UMR 5549, Ctr Rech Cerveau & Cognit, Toulouse, France
[3] Univ Toulouse 3, F-31062 Toulouse, France
[4] INSERM, APHM, Serv Neurol & Neuropsychol, F-13258 Marseille, France
[5] INSERM, U751, Lab Neurophysiol & Neuropsychol, F-13258 Marseille, France
关键词
D O I
10.1212/01.wnl.0000225076.73312.d4
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The DMS48 is a visual recognition memory test designed to detect memory changes in early Alzheimer disease (AD). Patients with amnestic mild cognitive impairment (aMCI) who succeeded on this task exhibited frontal hypoperfusion on SPECT. In contrast, failure was associated with temporomesial and temporoparietal hypoperfusion, a pattern usually described in the early stages of AD. It may possible to detect patients at high risk for AD within a population of aMCI.
引用
收藏
页码:356 / 358
页数:3
相关论文
共 9 条
[1]
NEUROFIBRILLARY TANGLES BUT NOT SENILE PLAQUES PARALLEL DURATION AND SEVERITY OF ALZHEIMERS-DISEASE [J].
ARRIAGADA, PV ;
GROWDON, JH ;
HEDLEYWHYTE, ET ;
HYMAN, BT .
NEUROLOGY, 1992, 42 (03) :631-639
[2]
Evaluation of visual recognition memory in MCI patients [J].
Barbeau, E ;
Didic, M ;
Tramoni, E ;
Felician, O ;
Joubert, S ;
Sontheimer, A ;
Ceccaldi, M ;
Poncet, M .
NEUROLOGY, 2004, 62 (08) :1317-1322
[3]
Preserved visual recognition memory in an amnesic patient with hippocampal lesions [J].
Barbeau, EJ ;
Felician, O ;
Joubert, S ;
Sontheimer, A ;
Ceccaldi, M ;
Poncet, M .
HIPPOCAMPUS, 2005, 15 (05) :587-596
[4]
Mild cognitive impairment -: Can FDG-PET predict who is to rapidly convert to Alzheimer's disease? [J].
Chételat, G ;
Desgranges, B ;
de la Sayette, V ;
Viader, F ;
Eustache, F ;
Baron, JC .
NEUROLOGY, 2003, 60 (08) :1374-1377
[5]
The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer's disease [J].
Delacourte, A ;
David, JP ;
Sergeant, N ;
Buée, L ;
Wattez, A ;
Vermersch, P ;
Ghozali, F ;
Fallet-Bianco, C ;
Pasquier, F ;
Lebert, F ;
Petit, H ;
Di Menza, C .
NEUROLOGY, 1999, 52 (06) :1158-1165
[6]
Amnestic MCI or prodromal Alzheimer's disease? [J].
Dubois, B ;
Albert, ML .
LANCET NEUROLOGY, 2004, 3 (04) :246-248
[7]
EFFECTS ON VISUAL RECOGNITION OF COMBINED AND SEPARATE ABLATIONS OF THE ENTORHINAL AND PERIRHINAL CORTEX IN RHESUS-MONKEYS [J].
MEUNIER, M ;
BACHEVALIER, J ;
MISHKIN, M ;
MURRAY, EA .
JOURNAL OF NEUROSCIENCE, 1993, 13 (12) :5418-5432
[8]
Retrosplenial cortex (BA 29/30) hypometabolism in mild cognitive impairment (prodromal Alzheimer's disease) [J].
Nestor, PJ ;
Fryer, TD ;
Ikeda, M ;
Hodges, JR .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2003, 18 (09) :2663-2667
[9]
Mild cognitive impairment - Clinical characterization and outcome [J].
Petersen, RC ;
Smith, GE ;
Waring, SC ;
Ivnik, RJ ;
Tangalos, EG ;
Kokmen, E .
ARCHIVES OF NEUROLOGY, 1999, 56 (03) :303-308