Synthesis of 5'-C-hydroxyalkylthymidines and their incorporation into oligodeoxynucleotides

被引：7

作者：

Wang, GY

Middleton, PJ

An, YZ

机构：

[1] Research Department, ICN Pharmaceuticals, Inc., Costa Mesa, CA 92626

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 14期

关键词：

D O I：

10.1016/S0040-4039(97)00386-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

5'-C-Hydroxymethyl-, 5'-C-hydroxyethyl, and 5'-C-hydroxypropylthymidine derivatives were prepared through four synthetic routes, which constitute an approach to introduce hydroxyalkyl of different lengths at C5' of thymidine. 5'-C-hydroxymethyl- and 5'-C-hydroxypropylthymidines were converted to the corresponding phosphoramidites and incorporated into oligodeoxynucleotides. (C) 1997 Elsevier Science Ltd.

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页码：2393 / 2396

页数：4

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