BH3-only proteins in tumorigenesis and malignant melanoma

被引：23

作者：

Karst, A. M. ^{[1
]}

Li, G. ^{[1
]}

机构：

[1] Univ British Columbia, Vancouver Coastal Hlth Res Inst, Jack Bell Res Ctr, Dept Dermatol & Skin Sci, Vancouver, BC V6H 326, Canada

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2007年 / 64卷 / 03期

关键词：

BH3-only protein; Bcl-2; family; apoptosis; tumorigenesis; melanoma;

D O I：

10.1007/s00018-006-6364-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

BH3-only proteins are a subset of the Bcl-2 family of apoptotic regulators. BH3-only proteins function as 'damage sensors' in the cell; they are activated in response to cellular stress or DNA damage, whereupon they initiate apoptosis. Apoptosis is the primary mechanism by which the body rids itself of genetically defective cells and is critical for preventing the accumulation of cells with tumorigenic potential. Therefore, dysregulation of BH3-only proteins may promote tumorigenesis. Furthermore, functional apoptosis pathways are required for the success of most cancer treatments, including chemotherapy. Resistance to chemotherapy, as seen with malignant melanoma, often reflects an inability of tumor cells to undergo apoptosis. By deciphering the roles of BH3-only proteins in tumorigenesis, we may learn how to manipulate cell death pathways to overcome apoptotic resistance. This review summarizes the current knowledge of BH3-only proteins and how they contribute to tumorigenesis, with particular attention given to studies involving melanoma.

引用

页码：318 / 330

页数：13

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