Elements and machinery of non-coding RNAs: toward their taxonomy

被引：61

作者：

Hirose, Tetsuro ^{[1
]}

Mishima, Yuichiro ^{[2
,3
]}

Tomari, Yukihide ^{[2
,3
]}

机构：

[1] Hokkaido Univ, Inst Med Genet, Sapporo, Hokkaido, Japan

[2] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo, Japan

[3] Univ Tokyo, Dept Med Genome Sci, Bunkyo Ku, Tokyo, Japan

来源：

EMBO REPORTS | 2014年 / 15卷 / 05期

基金：

日本学术振兴会;

关键词：

lncRNA; siRNA; CRISPR; miRNA; piRNA; PRIMARY PIRNA BIOGENESIS; PIWI-INTERACTING RNAS; SMALL-INTERFERING RNA; SMALL SILENCING RNAS; MEDIATED TRANSLATIONAL REPRESSION; ADAPTIVE BACTERIAL IMMUNITY; POLYCISTRONIC MESSENGER-RNA; SELFISH GENETIC ELEMENTS; CRISPR RNA; C-ELEGANS;

D O I：

10.1002/embr.201338390

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although recent transcriptome analyses have uncovered numerous non-coding RNAs (ncRNAs), their functions remain largely unknown. ncRNAs assemble with proteins and operate as ribonucleoprotein (RNP) machineries, formation of which is thought to be determined by specific fundamental elements embedded in the primary RNA transcripts. Knowledge about the relationships between RNA elements, RNP machinery, and molecular and physiological functions is critical for understanding the diverse roles of ncRNAs and may eventually allow their systematic classification or "taxonomy." In this review, we catalog and discuss representative small and long non-coding RNA classes, focusing on their currently known (and unknown) RNA elements and RNP machineries.

引用

页码：489 / 507

页数：19

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