DNA analysis by mass spectrometry - past, present and future

被引:39
作者
Tost, Jorg [1 ]
Gut, Ivo Glynne [1 ]
机构
[1] Ctr Natl Genotypage, F-91057 Evry, France
来源
JOURNAL OF MASS SPECTROMETRY | 2006年 / 41卷 / 08期
关键词
DNA; polymorphism; MALDI; sequencing; genotyping;
D O I
10.1002/jms.1096
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The analysis of deoxyribose nucleic acid (DNA) by mass spectrometry (MS) has evolved to where it can be used to analyze most known types of DNA and ribose nucleic acid (RNA) situations. It can efficiently deal with the analysis of DNA polymorphisms, sequences, haplotypes, human leukocyte antigen (HLA) typing, DNA methylation and RNA expression. Implementations of MS for these forms of DNA analyses are reviewed. The use of DNA analysis by MS is compared with competing technologies. Finally, an overview is given of worthwhile applications where the know-how gained so far could be used for future developments. Copyright (c) 2006 John Wiley & Sons, Ltd.
引用
收藏
页码:981 / 995
页数:15
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