A concise and stereoselective synthesis of the A-ring fragment of the gambieric acids

被引：61

作者：

Clark, JS ^{[1
]}

Fessard, TC ^{[1
]}

Wilson, C ^{[1
]}

机构：

[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 11期

关键词：

D O I：

10.1021/ol049483s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The A-ring fragment of the gambieric acids has been prepared by a short and efficient route. The key 3(2H)-furanone intermediate has been obtained by [2,3] rearrangement of an allylic oxonium ylide generated from intramolecular reaction of a crotyl ether with a copper carbenoid. A single stereogenic center has been set by using a chiral pool starting material and the other three have been established by using highly diastereoselective substrate-controlled transformations.

引用

页码：1773 / 1776

页数：4

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