学术探索
学术期刊
新闻热点
数据分析
智能评审

Detection of circulating fetal nucleic acids: a review of methods and applications

被引：38
作者：
Hung, E. C. W.
Chiu, R. W. K.
Lo, Y. M. D.
机构：
[1] Chinese Univ Hong Kong, Dept Chem Pathol, Hong Kong, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Ctr Res Circulating Fetal Nucle Acids, Li Ka Shing Inst Hlth Sci, Hong Kong, Hong Kong, Peoples R China
来源：
JOURNAL OF CLINICAL PATHOLOGY | 2009年 / 62卷 / 04期
关键词：
CELL-FREE DNA; MATERNAL PLASMA; MESSENGER-RNA; PRENATAL-DIAGNOSIS; PROGNOSTIC MARKER; CANCER-PATIENTS; MICROSATELLITE ALTERATIONS; PROMOTER HYPERMETHYLATION; QUANTITATIVE-ANALYSIS; POINT MUTATIONS;
D O I：
10.1136/jcp.2007.048470
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
The discovery of cell-free circulating fetal nucleic acids in maternal plasma has opened up new possibilities in non-invasive prenatal diagnosis. The rapid advancement of this field in the past decade is catalysed by the discovery of new classes of fetal nucleic acid markers and technological developments in nucleic acid detection and amplification. In this review, some of the more significant recent developments in this field will be discussed, including the detection of single molecule, chromosomal aneuploidies, single nucleotide variations and placental microRNAs in maternal plasma.
引用
收藏
页码：308 / 313
页数：6
相关论文
共 117 条
  • [1] Free fetal DNA in maternal plasma in anembryonic pregnancies: confirmation that the origin is the trophoblast
    Alberry, M.
    Maddocks, D.
    Jones, M.
    Hadi, M. Abdel
    Abdel-Fattah, S.
    Avent, N.
    Soothill, P. W.
    [J]. PRENATAL DIAGNOSIS, 2007, 27 (05) : 415 - 418
  • [2] MicroRNAs and other tiny endogenous RNAs in C-elegans
    Ambros, V
    Lee, RC
    Lavanway, A
    Williams, PT
    Jewell, D
    [J]. CURRENT BIOLOGY, 2003, 13 (10) : 807 - 818
  • [3] K-ras mutations are found in DNA extracted from the plasma of patients with colorectal cancer
    Anker, P
    Lefort, F
    Vasioukhin, V
    Lyautey, J
    Lederrey, C
    Chen, XQ
    Stroun, M
    Mulcahy, HE
    Farthing, MJG
    [J]. GASTROENTEROLOGY, 1997, 112 (04) : 1114 - 1120
  • [4] Cell-free DNA levels as a prognostic marker in acute myocardial infarction
    Antonatos, Dionisios
    Patsilinakos, Sotirios
    Spanodimos, Stavros
    Korkonikitas, Panagiotis
    Tsigas, D.
    [J]. CIRCULATING NUCLEIC ACIDS IN PLASMA AND SERUM IV, 2006, 1075 : 278 - 281
  • [5] Non-invasive diagnosis of fetal sex; utilisation of free fetal DNA in maternal plasma and ultrasound
    Avent, Neil D.
    Chitty, Lyn S.
    [J]. PRENATAL DIAGNOSIS, 2006, 26 (07) : 598 - 603
  • [6] Circulating fetal DNA: Its origin and diagnostic potential - A review
    Bianchi, DW
    [J]. PLACENTA, 2004, 25 : S93 - S101
  • [7] MicroRNA-cancer connection: The beginning of a new tale
    Calin, George Adrian
    Croce, Carlo Maria
    [J]. CANCER RESEARCH, 2006, 66 (15) : 7390 - 7394
  • [8] Circulating tumour-derived nucleic acids in cancer patients: potential applications as tumour markers
    Chan, K. C. A.
    Lo, Y. M. D.
    [J]. BRITISH JOURNAL OF CANCER, 2007, 96 (05) : 681 - 685
  • [9] Quantitative analysis of circulating methylated DNA as a biomarker for hepatocellular carcinoma
    Chan, K. C. Allen
    Lai, Paul B. S.
    Mok, Tony S. K.
    Chan, Henry L. Y.
    Ding, Chunming
    Yeung, S. W.
    Lo, Y. M. Dennis
    [J]. CLINICAL CHEMISTRY, 2008, 54 (09) : 1528 - 1536
  • [10] Hypermethylated RASSF1A in maternal plasma:: A universal fetal DNA marker that improves the reliability of noninvasive prenatal diagnosis
    Chan, K. C. Allen
    Ding, Chunming
    Gerovassili, Ageliki
    Yeung, Sze W.
    Chiu, Rossa W. K.
    Leung, Tse N.
    Lau, Tze K.
    Chim, Stephen S. C.
    Chung, Grace T. Y.
    Nicolaides, Kypros H.
    Lo, Y. M. Dennis
    [J]. CLINICAL CHEMISTRY, 2006, 52 (12) : 2211 - 2218
12345678910