Nanogrooved microdiscs for bottom-up modulation of osteogenic differentiation

被引：25

作者：

Bjorge, Isabel M. ^{[1
]}

Choi, Insung S. ^{[2
]}

Correia, Clara R. ^{[1
]}

Mano, Joao F. ^{[1
]}

机构：

[1] Univ Aveiro, Dept Chem, CICECO Aveiro Inst Mat, Campus Univ Santiago, P-3810193 Aveiro, Portugal

[2] Korea Adv Inst Sci & Technol, Dept Chem, Ctr Cell Encapsulat Res, Daejeon 34141, South Korea

来源：

NANOSCALE | 2019年 / 11卷 / 35期

基金：

欧洲研究理事会;

关键词：

MESENCHYMAL STEM-CELLS; SUBSTRATE TOPOGRAPHY; NANOSCALE; MICROPARTICLES; MORPHOLOGY; BEHAVIOR;

D O I：

10.1039/c9nr06267j

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Grooved topographical features have effectively modulated cell differentiation on two-dimensional substrates. To transpose patterning into a 3D environmment, nanogrooved microdiscs, "topodiscs", are produced as cell carriers for bottom-up cell-mediated assembly. While enhancing cell proliferation, topodiscs led to the formation of bone-like aggregates, even in culture medium lacking osteoinductive factors.

引用

收藏

页码：16214 / 16221

页数：8

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