17O-decoupled 1H spectroscopy and imaging with a surface coil:: STEAM decoupling

O-17-decoupled H-1 spin-echo imaging has been reported as a means of indirect O-17 detection, with potential application to measurement of blood how and metabolism. In its current form, O-17 decoupling requires large RF amplitudes and a 180 degrees refocusing pulse, complicating its application in volume and surface coils, respectively. To overcome this problem, we have developed an O-17-decoupled proton stimulated echo sequence ("STEAM decoupling") to allow O-17 detection with a surface coil. A high B-1 amplitude is easily generated, allowing complete decoupling of O-17 and H-1. Slice-selective, O-17-decoupled H-1 imaging is readily performed and the sequence is easily adapted for localized spectroscopy. Intrinsic correction for variations in B-1 and further compensation for B-1 inhomogeneity are discussed. (C) 2000 Academic Press.