Kinetics of Self-Immolation: Faster Signal Relay over a Longer Linear Distance?

被引：30

作者：

Lee, Ho Yong ^{[1
]}

Jiang, Xuan ^{[1
]}

Lee, Dongwhan ^{[1
]}

机构：

[1] Indiana Univ, Dept Chem, Bloomington, IN 47405 USA

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 10期

关键词：

MULTIPLE-RELEASE; DENDRIMERS; POLYMERS; PRODRUGS; CASCADE; SYSTEMS; SPACER; EVENT;

D O I：

10.1021/ol900433g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A counterintuitive observation of a faster signal relay over a longer linear distance prompted detailed kinetic studies of self-immolation reactions. With appropriate conformational bias, trigger-to-reporter signal transduction can take an efficient "shortcut" that outperforms conventional pathways involving repetitive quinone methide rearrangements and elimination.

引用

收藏

页码：2065 / 2068

页数：4

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