The experimental survey of protein-folding energy landscapes

被引：238

作者：

Oliveberg, Mikael ^{[1
]}

Wolynes, Peter G.

机构：

[1] Univ Stockholm, Arrhenius Labs Nat Sci, Dept Biochem & Biophys, S-10691 Stockholm, Sweden

[2] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

[3] Ctr Theoret Biol Phys, La Jolla, CA USA

来源：

QUARTERLY REVIEWS OF BIOPHYSICS | 2005年 / 38卷 / 03期

关键词：

D O I：

10.1017/S0033583506004185

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

We review what has been learned about the protein-folding problem from experimental kinetic studies. These studies reveal patterns of both great richness and surprising simplicity. The patterns can be interpreted in terms of proteins possessing an energy landscape which is largely, but not completely, funnel-like. Issues such as speed limitations of folding, the robustness of folding, the origin of barriers and cooperativity and the ensemble nature of transition states, intermediate and traps are assessed using the results from several experimental groups highlighting energy-landscape ideas as an interpretive framework.

引用

页码：245 / 288

页数：44

共 169 条

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