Alternative pre-mRNA splicing and proteome expansion in metazoans

被引:600
作者
Maniatis, T [1 ]
Tasic, B [1 ]
机构
[1] Harvard Univ, Dept Cellular & Mol Biol, Cambridge, MA 02138 USA
关键词
D O I
10.1038/418236a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The protein coding sequences of most eukaryotic messenger RNA precursors (pre mRNAs) are interrupted by non-coding sequences called introns. Pre-mRNA splicing is the process by which introns are removed and the protein coding elements assembled into mature mRNAs. Alternative pre-mRNA splicing selectively joins different protein coding elements to form mRNAs that encode proteins with distinct functions, and is therefore an important source of protein diversity. The elaboration of this mechanism may have had a significant role in the expansion of metazoan proteomes during evolution.
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页码:236 / 243
页数:8
相关论文
共 96 条
  • [71] Comparative genomics of the eukaryotes
    Rubin, GM
    Yandell, MD
    Wortman, JR
    Miklos, GLG
    Nelson, CR
    Hariharan, IK
    Fortini, ME
    Li, PW
    Apweiler, R
    Fleischmann, W
    Cherry, JM
    Henikoff, S
    Skupski, MP
    Misra, S
    Ashburner, M
    Birney, E
    Boguski, MS
    Brody, T
    Brokstein, P
    Celniker, SE
    Chervitz, SA
    Coates, D
    Cravchik, A
    Gabrielian, A
    Galle, RF
    Gelbart, WM
    George, RA
    Goldstein, LSB
    Gong, FC
    Guan, P
    Harris, NL
    Hay, BA
    Hoskins, RA
    Li, JY
    Li, ZY
    Hynes, RO
    Jones, SJM
    Kuehl, PM
    Lemaitre, B
    Littleton, JT
    Morrison, DK
    Mungall, C
    O'Farrell, PH
    Pickeral, OK
    Shue, C
    Vosshall, LB
    Zhang, J
    Zhao, Q
    Zheng, XQH
    Zhong, F
    [J]. SCIENCE, 2000, 287 (5461) : 2204 - 2215
  • [72] Schaal TD, 1999, MOL CELL BIOL, V19, P261
  • [73] Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity
    Schmucker, D
    Clemens, JC
    Shu, H
    Worby, CA
    Xiao, J
    Muda, M
    Dixon, JE
    Zipursky, SL
    [J]. CELL, 2000, 101 (06) : 671 - 684
  • [74] Schütt C, 2000, DEVELOPMENT, V127, P667
  • [75] SYNTHESIS AND REGULATION OF TRANS-MESSENGER RNA ENCODING THE IMMUNOGLOBULIN-EPSILON HEAVY-CHAIN
    SHIMIZU, A
    HONJO, T
    [J]. FASEB JOURNAL, 1993, 7 (01) : 149 - 154
  • [76] Experimental annotation of the human genome using microarray technology
    Shoemaker, DD
    Schadt, EE
    Armour, CD
    He, YD
    Garrett-Engele, P
    McDonagh, PD
    Loerch, PM
    Leonardson, A
    Lum, PY
    Cavet, G
    Wu, LF
    Altschuler, SJ
    Edwards, S
    King, J
    Tsang, JS
    Schimmack, G
    Schelter, JM
    Koch, J
    Ziman, M
    Marton, MJ
    Li, B
    Cundiff, P
    Ward, T
    Castle, J
    Krolewski, M
    Meyer, MR
    Mao, M
    Burchard, J
    Kidd, MJ
    Dai, H
    Phillips, JW
    Linsley, PS
    Stoughton, R
    Scherer, S
    Boguski, MS
    [J]. NATURE, 2001, 409 (6822) : 922 - +
  • [77] Alternative pre-mRNA splicing:: the logic of combinatorial control
    Smith, CWJ
    Valcárcel, J
    [J]. TRENDS IN BIOCHEMICAL SCIENCES, 2000, 25 (08) : 381 - 388
  • [78] Piecing together the significance of splicing
    Sorek, R
    Amitai, M
    [J]. NATURE BIOTECHNOLOGY, 2001, 19 (03) : 196 - 196
  • [79] Mechanical devices of the spliceosome: Motors, clocks, springs, and things
    Staley, JP
    Guthrie, C
    [J]. CELL, 1998, 92 (03) : 315 - 326
  • [80] Composition and functional characterization of the yeast spliceosomal Penta-snRNP
    Stevens, SW
    Ryan, DE
    Ge, HY
    Moore, RE
    Young, MK
    Lee, TD
    Abelson, J
    [J]. MOLECULAR CELL, 2002, 9 (01) : 31 - 44