Solid phase synthesis of hydantoins by thermal cyclization and screening of reaction conditions using APOS 1200

被引：10

作者：

Karnbrock, W

Deeg, M

Gerhardt, J

Rapp, W

机构：

[1] Rapp Polymere GmbH, D-72072 Tubingen, Germany

[2] CAT GmbH & Co KG, D-72070 Tubingen, Germany

[3] Univ Klin Tubingen, Zentrum Med Forsch, D-72072 Tubingen, Germany

来源：

MOLECULAR DIVERSITY | 1998年 / 4卷 / 03期

关键词：

APOS; 1200; combinatorial chemistry; FT-ATR-IR spectroscopy; hydantoin; solid-phase synthesis; TentaGel; thermal cyclization;

D O I：

10.1023/A:1009659303984

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel strategy for solid-phase synthesis of hydantoins with high optical purity is described using a thermal pH-neutral cyclization and simultaneous release from resin. Hereby even hydantoins bearing a pH-sensitive side chain (protection) are available. The reaction conditions are well screened applying the parallel organic synthesizer APOS 1200.

引用

页码：165 / 171

页数：7

共 15 条

[1]

Balkenhohl F., 1996, ANGEW CHEM, V108, P2436

[2] Synthesis of hydantoins via N,N′-ureas derived from polymer-bound amino acids [J].